Workstation is Windows 7 Enterprise, SP1, 64-bit, running on VMWare.
EnterpriseOne 9.1 with Update 2, and Tools Release 9.1.5.7.

Trying to use OWDLC 10.4 to turn on debugging, and the Logging Status column says INACCESSIBLE, with an "Error 5: Access is denied" message in the lower left corner.

Have you seen this message before? Any idea what it might be?